3-Thiophenecarboxylic acid, tetrahydro-4-oxo-, methyl ester → HCID 46833175, compound

HRID 2366077Notes

Reaction equation

HRID 2366077 reaction equation
[C:1]([C:5]1[N:9]=[C:8]([C:10]2[CH:11]=[CH:12][C:13]([NH:16][NH2:17])=[N:14][CH:15]=2)[O:7][N:6]=1)([CH3:4])([CH3:3])[CH3:2].O=[C:19]1[CH2:23][S:22][CH2:21][CH:20]1[C:24](OC)=[O:25]>>[C:1]([C:5]1[N:9]=[C:8]([C:10]2[CH:11]=[CH:12][C:13]([N:16]3[C:24](=[O:25])[C:20]4[CH2:21][S:22][CH2:23][C:19]=4[NH:17]3)=[N:14][CH:15]=2)[O:7][N:6]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 984243-Thiophenecarboxylic acid, tetrahydro-4-oxo-, methyl esterHCID 53337861HCID 53337861, compound

Product 1

HCID 46833175HCID 46833175, compoundYield 38%

Procedure

According to the process described in Example 1, starting with 0.6 g of 5-(3-tert-butyl-1,2,4-oxadiazol-5-yl)-2-hydrazinylpyridine and 0.41 g of methyl 4-oxotetrahydrothiophene-3-carboxylate, 0.32 g of 2-[5-(3-tert-butyl-1,2,4-oxadiazol-5-yl)pyridin-2-yl]-1,2,4,6-tetrahydro-3H-thieno[3,4-c]pyrazol-3-one is obtained in the form of a white solid.

Sources & evidence

ORD record
ord-0544a4c0ea4b499a863996ab296d57eb
Source dataset
uspto-grants-2014_04
Patent number
US08697731B2

Reaction notes

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