反应详情

3-[5-(Pyrid-2-ylmethoxy)-3-(2-methyl-2-propylthio)-1-[4-(2-methoxypyrid-5-yl)benzyl]indol-2-yl]-2,2-dimethylpropionic acid (444 g, 0.498 mol) was added to a reactor containing 2.1 L of EtOH and stirred. A NaOH solution (29 g in 218 mL of water) was added to the reactor and stirred at ambient temperature for about 30 mins. The reaction was concentrated under vacuum at a temperature of between 40 and 50° C. under a reduced pressure of between 10 to 30 mm Hg. The compound was subsequently dried under vacuum at a temperature of between 40 and 45° C. under a reduced pressure of between 5 and 10 mm Hg to afford 460 g of desired product in near quantitative yield.

1. stirringstirred at ambient temperature for about 30 mins
2. concentrationThe reaction was concentrated under vacuum at a temperature of between 40 and 50° C. under a reduced pressure of between 10 to 30 mm Hg
3. customThe compound was subsequently dried under vacuum at a temperature of between 40 and 45° C. under a reduced pressure of between 5 and 10 mm Hg