HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → Lithium 3-[5-(pyrid-2-ylmethoxy)-3-(2-methyl-2-propylthio)-1-[4-(2-methoxypyrid-5-yl)benzyl]indol-2-yl]-2,2-dimethylpropionate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | AM-103 free acid | HCID 16224456 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Lithium 3-[5-(pyrid-2-ylmethoxy)-3-(2-methyl-2-propylthio)-1-[4-(2-methoxypyrid-5-yl)benzyl]indol-2-yl]-2,2-dimethylpropionate | HCID 68447833 | — |
Reaction Steps
3-[5-(Pyrid-2-ylmethoxy)-3-(2-methyl-2-propylthio)-1-[4-(2-methoxypyrid-5-yl)benzyl]indol-2-yl]-2,2-dimethylpropionic acid (1 eq.) is added to a reactor containing ethanol and stirred. A LiOH solution in water (1.05 eq.) is added to the reactor and stirred at ambient temperature. After removal of the solvent, lithium 3-[5-(pyrid-2-ylmethoxy)-3-(2-methyl-2-propylthio)-1-[4-(2-methoxypyrid-5-yl)benzyl]indol-2-yl]-2,2-dimethylpropionate is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08697730B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-fc1bd7c7dd844261aaf372c2eec730fb |
| Source note | uspto-grants-2014_04 |