3-Ethyl-5,5-dimethyl-4,5,6,7-tetrahydro-benzo[c]thiophene-1-carboxylic acid → 4-[5-(3-Ethyl-5,5-dimethyl-4,5,6,7-tetrahydro-benzo[c]thiophen-1-yl)-[1,3,4]oxadiazol-2-yl]-2,6-dimethyl-pyridine

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Reaction Steps

4-[5-(3-Ethyl-5,5-dimethyl-4,5,6,7-tetrahydro-benzo[c]thiophen-1-yl)-[1,3,4]oxadiazol-2-yl]-2,6-dimethyl-pyridine is synthesized from 3-ethyl-5,5-dimethyl-4,5,6,7-tetrahydro-benzo[c]thiophene-1-carboxylic acid and 2,6-dimethyl-isonicotinic acid hydrazide hydrochloride in analogy to Example 9; LC-MS: tR=0.93 min, [M+1]=368.44; 1H NMR (CD3OD): δ 7.66 (s, 2 H), 3.09 (t, J=6.7 Hz, 2 H), 2.80 (q, J=7.6 Hz, 2 H), 2.60 (s, 6 H), 2.39 (s, 2 H), 1.67 (t, J=6.7 Hz, 2 H), 1.29 (t, J=7.6 Hz, 3 H), 1.03 (s, 6 H).

Provenance & Evidence