Cesium carbonate → 2-(4-(6-(2-(2,6-Dichlorophenyl)thiazolo[5,4-c]pyridin-4-ylamino)-2-methylpyrimidin-4-yl)piperazin-1-yl)ethanol

Participants

Reaction Steps

To a microwave tube was added 4-bromo-2-(2,6-dichlorophenyl)thiazolo[5,4-c]pyridine (60 mg, 0.17 mmol), 2-(4-(6-amino-2-methylpyrimidin-4-yl)piperazin-1-yl)ethanol (0.052 g, 0.22 mmol), Pd2(dba)3 (0.013 g, 0.017 mmol), XantPhos (0.017 g, 0.034 mmol) and Cs2CO3 (0.11 g, 0.34 mmol) in dioxane (3.0 mL). The mixture was degassed with N2 for 10 minutes and then irradiated in a microwave reactor at 160° C. for 2 hours. After cooling to room temperature the solid was removed via filtration. The filtrate was concentrated under reduced pressure and the residue was purified with reverse phase column chromatography, eluting with a 0-60% gradient of CH3CN in 0.5% NH4HCO3 to give the desired product as a white solid (15 mg, 18% yield). 1H NMR (500 MHz, DMSO-d6): δ 10.16 (s, 1H), 8.38 (d, J=5.5 Hz, 1H), 7.74-7.70 (m, 4H), 6.70 (s, 1H), 4.46 (t, J=5.5 Hz, 1H), 3.54-3.52 (m, 6H), 2.51-2.47 (m, 4H), 2.44-2.41 (m, 2H), 2.32 (s, 3H). LCMS (Method A): RT=5.52 min, m/z: 516.1 [M+H+].

Provenance & Evidence