反应详情

To a stirred suspension of pyrimidine-4,6-diamine (500 mg, 4.55 mmol) in dioxane (20 mL) was added acetic anhydride (465 mg, 4.55 mmol) and the resulting mixture was heated under reflux for 15 hours. The reaction was cooled to room temperature and the resulting precipitate was collected by filtration. The filtercake was dissolved in 1N HCl and the pH of the aqueous phase adjusted to 7 by the addition of 1N NaOH. The resulting white precipitate was collected by filtration and dried to afford the desired product as a white solid (420 mg, 61% yield). LCMS (ESI) m/z: 152.0 [M+H+].

1. temperaturethe resulting mixture was heated
2. temperatureunder reflux for 15 hours
3. filtrationthe resulting precipitate was collected by filtration
4. dissolutionThe filtercake was dissolved in 1N HCl
5. additionthe pH of the aqueous phase adjusted to 7 by the addition of 1N NaOH
6. filtrationThe resulting white precipitate was collected by filtration
7. customdried