反应详情

A solution of 2-methoxycarbonyl phenylisocyanate (21.7 g) in ethyl acetate (116 g) is added dropwise to N-methylethanolamine (22.5 g), the mixture being stirred and cooled to keep the temperature below 36° C. The upper layer of the resulting mixture is separated and distilled at 60° C. under reduced pressure to remove ethyl acetate. The white solid residue remaining is triturated with ether, filtered, washed with ether and then dried in air to give N-(2-methoxycarbonylphenyl)-N'-methyl-N'-(2-hydroxyethyl)urea (22.4 g), m.pt. 90° C.

1. temperaturecooled
2. customthe temperature below 36° C
3. customThe upper layer of the resulting mixture is separated
4. distillationdistilled at 60° C. under reduced pressure
5. customto remove ethyl acetate
6. customThe white solid residue remaining is triturated with ether
7. filtrationfiltered
8. washwashed with ether
9. customdried in air