反应详情

A solution of 2,6-dichloro-4-iodobenzoic acid (5.50 g, 17.4 mmol) in thionyl chloride (52 mL) was heated under reflux for 2 hours then diluted with toluene and concentrated under reduced pressure. The resultant residue was partitioned between EtOAc and saturated aqueous sodium bicarbonate solution. The organic layer was dried over Na2SO4 and concentrated under reduced pressure to give the desired compound as a yellow oil (5.75 g, 99% yield). 1H NMR (400 MHz, CDCl3) δ 7.75 (s, 2H).

1. temperatureunder reflux for 2 hours
2. concentrationconcentrated under reduced pressure
3. customThe resultant residue was partitioned between EtOAc and saturated aqueous sodium bicarbonate solution
4. dry with materialThe organic layer was dried over Na2SO4
5. concentrationconcentrated under reduced pressure