HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2366232Generated: October 31, 2026
Ammonium Hydroxide → 6-Chloro-5-fluoropyrimidin-4-amine
https://huagongshe.com/reaction/2366232
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | 4,6-Dichloro-5-fluoropyrimidine | HCID 11286675 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | 6-Chloro-5-fluoropyrimidin-4-amine | HCID 53487969 | 89% |
Reaction Steps
A mixture of 4,6-dichloro-5-fluoro-pyrimidine (1.67 g, 10.0 mmol), n-butanol (6 mL) and 28% ammonium hydroxide (12 mL) in a sealed tube was heated at 90° C. for 2 hours. The precipitated white crystals were collected by filtration to give the desired compound (1.31 g, 89% yield). LCMS (ESI) m/z: 147.9 [M+H+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08697708B2 |
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| Source dataset | uspto-grants-2014_04 |
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| ORD ID | ord-455ee7ee94dd4f219cf0ceb917732567 |
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| Source note | uspto-grants-2014_04 |
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