Cesium carbonate → HCID 66803515, compound

Participants

Reaction Steps

To a microwave tube was added 4-bromo-2-(2,6-dichlorophenyl)thiazolo[5,4-c]pyridine (100 mg, 0.280 mmol), 2-((6-aminopyrimidin-4-yl)methyl)isoindoline-1,3-dione (100 mg, 0.390 mmol), Pd2(dba)3 (32 mg, 0.035 mmol), XantPhos (30 mg, 0.052 mmol), Cs2CO3 (250 mg, 0.770 mmol) in dioxane (5.0 mL). The mixture was degassed with N2 for 10 min. The resulting mixture was irradiated in a microwave reactor at 160° C. for 2 hours and then cooled to room temperature. Insoluble solid was removed via filtration, and the residue was purified with reverse phase column chromatography eluting with a 0-60% gradient of CH3CN in 0.5% NH4HCO3 to give the desired product as a white solid (100 mg, 70% yield). LCMS: m/z: 533.1 [M+H+].

Provenance & Evidence