HCID 66803505, compound → HCID 66801483, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of [2-(2-chloro-4-cyano-6-fluorophenyl)thiazolo[5,4-c]pyridin-4-yl]-carbamic acid tert-butyl ester (0.320 mmol) in HCl (4N in dioxane, 2.5 mL) was heated at 50° C. for 3 hours in a sealed vial. After cooling to room temperature, the volatiles were removed under reduced pressure and the resultant residue was partitioned between EtOAc and a saturated solution of NaHCO3. The aqueous phase was extracted with EtOAc, and the combined organic layers were washed with brine, dried (Na2SO4) and concentrated to dryness under reduced pressure to afford the title compound as a yellow solid (76 mg, 78% yield over two steps). 1H NMR (400 MHz, CDCl3): δ 8.21 (d, J=5.8 Hz, 1H), 7.69 (t, J=1.4 Hz, 1H), 7.53-7.46 (m, 2H), 4.84 (s, 2H).

Provenance & Evidence