HCID 66803800, compound → HCID 66801247, compound

Participants

Reaction Conditions

Reaction Steps

HCl (4N in dioxane, 10 mL) was added to [2-(2-chloro-6-fluorophenyl)-7-fluorothiazolo[5,4-c]pyridin-4-yl]-carbamic acid tert-butyl ester (0.350 g, 0.88 mmol) and the reaction mixture was heated at 50° C. for 3 hours. After cooling to room temperature, the volatiles were removed under reduced pressure to afford the title compound as an off-white solid (270 mg, quantitative). 1H NMR (400 MHz, CDCl3): δ 7.84 (s, 1H), 7.61-7.49 (m, 1H), 7.44 (d, J=8.1 Hz, 1H), 7.25 (t, J=8.7 Hz, 1H), 2.90 (br s, 2H).

Provenance & Evidence