Potassium Carbonate → HCID 86669011, compound

Participants

Reaction Conditions

Reaction Steps

Trimethylsilyl bromide (1.2 mL, 9.0 mmol) was added to a solution of 4-chloro-2-(2,6-dichlorophenyl)-7-fluorothiazolo[5,4-c]pyridine (1.0 g, 3.0 mmol) in propionitrile (30 mL) at room temperature under argon. The reaction mixture was heated at 85° C. in a sealed vial for 16 hours. The resultant mixture was poured in an ice-cooled saturated solution of potassium carbonate. The product was extracted with DCM (×2) and the combined organic layers were dried (Na2SO4) and concentrated under reduced pressure to afford the title compound as an off-white solid (1.17 g, quantitative). LCMS (Method E): RT=4.32 min, m/z: 379 [M+H+].

Provenance & Evidence