Thionyl Chloride → 2,6-Dichloro-4-cyano-N-(3,5-difluoropyridin-4-yl)-benzimidoyl chloride

Participants

Reaction Conditions

Reaction Steps

A stirred suspension of 2,6-dichloro-4-cyano-N-(3,5-difluoropyridin-4-yl)-benzamide (1.35 g, 4.12 mmol) in thionyl chloride (14 mL) was heated at 85° C. for 5 hours and then at 80° C. for 56 hours under a nitrogen atmosphere. After cooling to room temperature, the volatiles were removed under reduced pressure to afford the title compound as an orange solid (1.5 g, quantitative). LCMS (Method D): RT=4.01 min, m/z: 346 [M+H+].

Provenance & Evidence