Thionyl Chloride → HCID 86669022, compound

Participants

Reaction Steps

A mixture of 2-fluoro-N-(3,5-difluoropyridin-4-yl)-6-nitrobenzamide (10.81 g, 36.4 mmol) in thionyl chloride (95 mL) was heated under reflux for 3 days under a nitrogen atmosphere. After cooling to room temperature, the volatiles were removed under reduced pressure and the resultant residue was azeotroped with toluene (×3) to afford the title compound as a yellow/pale brown solid (12.05 g, quantitative). LCMS (Method D): RT=3.64 min, m/z: 316 [M+H+].

Provenance & Evidence