Sodium Sulfite → HCID 66801400, compound

Participants

Reaction Steps

To a solution of 7-bromo-2-(2-chloro-6-fluoro-phenyl)thiazolo[5,4-c]pyridine (2.0 mmol, 690 mg) in DCM (20 mL) was added mCPBA (5. 2 mmol, 890 mg). The mixture was stirred at room temperature for 5 hours. A solution of 1 M Na2SO3 (10 mL) was then added. The mixture was then stirred at room temperature for 1 hour. A solution of sat. NaHCO3 was added. The layers were separated. The aqueous layer was extracted with DCM. Then the combined organics were dried (Na2SO4), filtered and concentrated to give the title compound as an off-white solid which was used in the next step without purification. LCMS (ESI) m/z 360.9 [M+H+].

Provenance & Evidence