Formic Acid → HCID 86669026, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-(2-chloro-6-fluoro-phenyl)-4-[(6-methylpyrimidin-4-yl)amino]thiazolo[5,4-c]pyridine-7-carbonitrile (0.0500 mmol, 61.8 mg) in formic acid (2.25 mL) and water (0.75 mL) was added Al—Ni Alloy (130 mg). The mixture was heated at 100° C. for 4 hours. The mixture was then cooled to room temperature and filtered through celite, washed with 95% EtOH, concentrated via rotavap to give a yellow solid which was used in the next step without purification. LCMS (ESI) m/z 400.1 [M+H+].

Provenance & Evidence