反应详情

To a stirred solution of biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-{[(R)-2-(tert-butyldimethylsilanyloxy)-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]-methyl}phenylcarbamoyl)butyl]methylcarbamoyl}ethyl)piperidin-4-yl ester (3.87 g, 4.28 mmol) in a mixture of DCM (20 mL) and DMF (2.5 mL) was added triethylamine trihydrofluoride (2.1 mL, 13 mmol). The resulting mixture was stirred at room temperature overnight. DCM (68 mL) was added to the reaction mixture and then, with stirring, EtOAc (68 mL) was added dropwise. A light colored precipitate formed resulting in a slurry. The slurry mixture was filtered through a medium porosity fritted glass filter and the filter cake was rinsed with EtOAc (2×10 mL) and then pressed dry on a nitrogen press to give the title compound (3.73 g, 99% yield).

1. stirringwith stirring
2. customformed
3. customresulting in a slurry
4. filtrationThe slurry mixture was filtered through a medium porosity fritted glass
5. filtrationfilter
6. washthe filter cake was rinsed with EtOAc (2×10 mL)
7. custompressed dry on a nitrogen press