HuagongsheHuagongshe Chemistry Print Report · For research reference only
N,N,N',N'-Tetramethylethylenediamine → 1,2,3,4-Tetrahydropyrido[2,3-b]pyrazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N,N,N',N'-Tetramethylethylenediamine | HCID 8037 | — |
| Reactant | 5-Bromo-6-chloropyridine-3-sulfonamide | HCID 4730022 | — |
| Reactant | HCID 86661595 | HCID 86661595 | — |
| Product | 1,2,3,4-Tetrahydropyrido[2,3-b]pyrazine | HCID 12531338 | — |
Reaction Steps
The 5-bromo-6-chloro-3-pyridinesulfonamide derivative (lix) (prepared from the commercially available 5-bromo-6-chloropyridine sulfonyl chloride as shown in Scheme 18) is condensed with diamine (lxxix), (lxxx) or N1,N1,N2,N2-tetramethylethane-1,2-diamine to form tetrahydropyridopyrazine derivative (I-e), (I-f) or (I-d), respectively, as shown.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08697739B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-5201fa113ba345599e72b16a2a8fb461 |
| Source note | uspto-grants-2014_04 |