3,4-Dimethoxybenzeneacetonitrile → HCID 11965248, compound

HRID 2366360Notes

Reaction equation

HRID 2366360 reaction equation
[N+:1]([C:4]1[S:8][C:7]([CH:9]=O)=[CH:6][CH:5]=1)([O-:3])=[O:2].[CH3:11][O:12][C:13]1[CH:14]=[C:15]([CH:19]=[CH:20][C:21]=1[O:22][CH3:23])[CH2:16][C:17]#[N:18]>>[CH3:11][O:12][C:13]1[CH:14]=[C:15](/[C:16](=[CH:9]/[C:7]2[S:8][C:4]([N+:1]([O-:3])=[O:2])=[CH:5][CH:6]=2)/[C:17]#[N:18])[CH:19]=[CH:20][C:21]=1[O:22][CH3:23]

Participants

3

Reactant 2

HCID 667273,4-DimethoxybenzeneacetonitrileHCID 782815-Nitrothiophene-2-carboxaldehyde

Product 1

HCID 11965248HCID 11965248, compoundYield 8.5%

Procedure

5-Nitrothiophene-2-carboxaldehyde (3.14 g) was condensed with 3,4-dimethoxybenzyl cyanide (3.54 g) through Method A (production step 2), to thereby yield the target product (yield: 540 mg, 8.5%).

Sources & evidence

ORD record
ord-c960949d23464997ba76d12cc498b6e6
Source dataset
uspto-grants-2014_04
Patent number
US08697742B2

Reaction notes

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