3,4-Dimethoxybenzeneacetonitrile → HCID 11965249, compound

HRID 2366361Notes

Reaction equation

HRID 2366361 reaction equation
[Br:1][C:2]1[S:6][C:5]([CH:7]=O)=[CH:4][CH:3]=1.[CH3:9][O:10][C:11]1[CH:12]=[C:13]([CH:17]=[CH:18][C:19]=1[O:20][CH3:21])[CH2:14][C:15]#[N:16]>>[Br:1][C:2]1[S:6][C:5](/[CH:7]=[C:14](/[C:13]2[CH:17]=[CH:18][C:19]([O:20][CH3:21])=[C:11]([O:10][CH3:9])[CH:12]=2)\[C:15]#[N:16])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 667273,4-DimethoxybenzeneacetonitrileHCID 784285-Bromothiophene-2-carbaldehyde

Product 1

HCID 11965249HCID 11965249, compoundYield 51.4%

Procedure

5-Bromothiophene-2-carboxaldehyde (381 mg) was condensed with 3,4-dimethoxybenzyl cyanide (355 mg) through Method A (production step 2), to thereby yield the target product (yield: 359 mg, 51%).

Sources & evidence

ORD record
ord-603626f1a3dc43fc9da3df06abd2f207
Source dataset
uspto-grants-2014_04
Patent number
US08697742B2

Reaction notes

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