HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methylpiperazine → HCID 11965496, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | 3,4-Dimethoxybenzeneacetonitrile | HCID 66727 | — |
| Reactant | 5-Bromofuran-2-carbaldehyde | HCID 600328 | — |
| Reactant | 5-(4-Methyl-1-piperazinyl)-2-furancarboxaldehyde | HCID 4738489 | — |
| Product | HCID 11965496 | HCID 11965496 | 30.4% |
Reaction Steps
Through the procedure as employed in Production step 1, an amine moiety derived from 1-methylpiperazine (1.03 g) was introduced into 5-bromo-2-furaldehyde (602 mg), to thereby yield 5-(4-methyl-piperazin-1-yl)-furan-2-carbaldehyde (yield: 447 mg, 67%). The produced 5-(4-methyl-piperazin-1-yl)-furan-2-carbaldehyde (388 mg) was condensed with 3,4-dimethoxybenzyl cyanide (355 mg) through Method A (production step 2), to thereby yield the target product (yield: 215 mg, 30%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08697742B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-8c325e1f509049049ba5fdab5f522536 |
| Source note | uspto-grants-2014_04 |