反应详情

温度

-8 °C

A sample of N-acetyl-3-acetoxyl-5-p-chlorophenylpyrrole (16) (2.8 g; 0.01 mol) was deoxygenated for ten minutes with a stream of N2. The solids were then dissolved in deoxygenated methanol (30 mL) which was then chilled to -8° C. At once was added a cold deoxygenated solution of NaOH (1.6 g; 0.04 mol) in 20 mL H2O, which solution was then heated briefly to 15° C. and then immediately cooled to -5° C.; after 25 minutes the clear solution was treated with a cold deoxygenated solution of citric acid (4.2 g; 0.02 mol) in 15 mL H2O. The temperature rose briefly to 5° C. After 0.5 hr. stirring at -5° C., the solids were collected by filtration and washed with cold deoxygenated H2O. The pale green product was dried under vacuum at room temperature over P2O5 for several days (1.3 g; 68%); TLC Rf=0.19 (CHCl3 :EtOH, 9:1); IR (KCl) showed no evidence for C=O absorption.

1. temperaturewas then heated briefly to 15° C.
2. temperatureimmediately cooled to -5° C.
3. customrose briefly to 5° C
4. filtrationthe solids were collected by filtration
5. washwashed
6. customwith cold deoxygenated H2O
7. dry with materialThe pale green product was dried under vacuum at room temperature over P2O5 for several days (1.3 g; 68%)
8. customfor C=O absorption