3,4-Dimethoxybenzeneacetonitrile → HCID 11965578, compound

HRID 2366395Notes

Reaction equation

HRID 2366395 reaction equation
[CH2:1]([N:8]1[C:12]([CH:13]=O)=[CH:11][N:10]=[C:9]1[S:15][CH3:16])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:17][O:18][C:19]1[CH:20]=[C:21]([CH:25]=[CH:26][C:27]=1[O:28][CH3:29])[CH2:22][C:23]#[N:24]>>[CH2:1]([N:8]1[C:12](/[CH:13]=[C:22](/[C:21]2[CH:25]=[CH:26][C:27]([O:28][CH3:29])=[C:19]([O:18][CH3:17])[CH:20]=2)\[C:23]#[N:24])=[CH:11][N:10]=[C:9]1[S:15][CH3:16])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 667273,4-DimethoxybenzeneacetonitrileHCID 3434141-benzyl-2-(methylsulfanyl)-1H-imidazole-5-carbaldehyde

Product 1

HCID 11965578HCID 11965578, compoundYield 92.4%

Procedure

1-Benzyl-2-(methylsulfanyl)-1H-imidazole-5-carbaldehyde (465 mg) was condensed with 3,4-dimethoxybenzyl cyanide (354 mg) through Method A (production step 2), to thereby yield the target product (yield: 723 mg, 92%).

Sources & evidence

ORD record
ord-6ab439e38ca54c608883a8ecbfac0568
Source dataset
uspto-grants-2014_04
Patent number
US08697742B2

Reaction notes

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