3,4-Dimethoxybenzeneacetonitrile → HCID 11965579, compound

HRID 2366396Notes

Reaction equation

HRID 2366396 reaction equation
[CH3:1][C:2]1[N:3]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[S:5][C:6]=1[CH:7]=O.[CH3:15][O:16][C:17]1[CH:18]=[C:19]([CH:23]=[CH:24][C:25]=1[O:26][CH3:27])[CH2:20][C:21]#[N:22]>>[CH3:15][O:16][C:17]1[CH:18]=[C:19](/[C:20](=[CH:7]/[C:6]2[S:5][C:4]([C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=3)=[N:3][C:2]=2[CH3:1])/[C:21]#[N:22])[CH:23]=[CH:24][C:25]=1[O:26][CH3:27]

Participants

3

Reactant 2

HCID 667273,4-DimethoxybenzeneacetonitrileHCID 27954914-methyl-2-phenyl-1,3-thiazole-5-carbaldehyde

Product 1

HCID 11965579HCID 11965579, compoundYield 92.1%

Procedure

4-Methyl-2-phenyl-1,3-thiazole-5-carbaldehyde (407 mg) was condensed with 3,4-dimethoxybenzyl cyanide (354 mg) through Method A (production step 2), to thereby yield the target product (yield: 667 mg, 92%).

Sources & evidence

ORD record
ord-b54839898edf4b4f9c49b58b44c1fe84
Source dataset
uspto-grants-2014_04
Patent number
US08697742B2

Reaction notes

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