HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,4-Dimethoxybenzeneacetonitrile → HCID 11965580, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,4-Dimethoxybenzeneacetonitrile | HCID 66727 | — |
| Reactant | 1,2-Ethanediamine, N1,N1,N2-trimethyl- | HCID 67338 | — |
| Reactant | 5-Bromofuran-2-carbaldehyde | HCID 600328 | — |
| Reactant | 5-(4-Methyl-1-piperazinyl)-2-furancarboxaldehyde | HCID 4738489 | — |
| Product | HCID 11965580 | HCID 11965580 | 96.9% |
Reaction Steps
Through the procedure as employed in Production step 1, an amine moiety derived from N,N,N′-trimethylethylenediamine (3.06 g) was introduced into 5-bromo-2-furaldehyde (1.75 g), to thereby yield 5-(4-methyl-piperazin-1-yl)-furan-2-carbaldehyde (yield: 1.18 g, 60%). The produced 5-(4-methyl-piperazin-1-yl)-furan-2-carbaldehyde (1.18 g) was condensed with 3,4-dimethoxybenzyl cyanide (1.06 g) through Method A (production step 2), to thereby yield the target product (yield: 2.06 g, 96%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08697742B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-f7ded62eb2de4463b966541ace31a22a |
| Source note | uspto-grants-2014_04 |