Veratraldehyde → HCID 11965655, compound

HRID 2366405Notes

Reaction equation

HRID 2366405 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][C:7]#[N:8].[CH3:9][O:10][C:11]1[CH:12]=[C:13]([CH:16]=[CH:17][C:18]=1[O:19][CH3:20])[CH:14]=O>>[CH3:9][O:10][C:11]1[CH:12]=[C:13](/[CH:14]=[C:6](/[C:2]2[S:1][CH:5]=[CH:4][CH:3]=2)\[C:7]#[N:8])[CH:16]=[CH:17][C:18]=1[O:19][CH3:20]

Participants

3

Reactant 2

HCID 8419VeratraldehydeHCID 728802-Thienylacetonitrile

Product 1

HCID 11965655HCID 11965655, compoundYield 48.3%

Procedure

2-Thiopheneacetonitrile (246 mg) was condensed with 3,4-dimethoxybenzaldehyde (332 mg) through Method B (production step 2), to thereby yield the target product (yield: 262 mg, 48%).

Sources & evidence

ORD record
ord-e52a9454359047b78cf467cb70b26e11
Source dataset
uspto-grants-2014_04
Patent number
US08697742B2

Reaction notes

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