4-Methylmorpholine → HCID 67227628, compound

Participants

Reaction Steps

Compound 18 (235 mg) was dissolved in methylene chloride (10 mL), and 2-chloro-4,6-dimethoxy-1,3,5-triazine (105 mg) and N-methylmorpholine (66 μL) were added to the solution, followed by stirring for 30 minutes with ice cooling. Subsequently, N,N-diethylethylenediamine (85 μL) and N-methylmorpholine (110 μL) were added to the mixture, followed by stirring at room temperature for 17 hours. The solvent was evaporated to dryness, and the residue was purified by silica gel column chromatography (CHCl3-MeOH), to thereby yield the target product (yield: 287 mg, 95%).

Provenance & Evidence