反应详情

Compound 6 (2.00 g) was dissolved in pyridine (50 mL), and 1-chlorocarbonyl-4-piperidinopiperidine (2.50 g) was added to the solution, followed by stirring under reflux for 2 hours. After completion of reaction, methanol was added to the reaction mixture, followed by stirring for 30 minutes. The solvent was evaporated under reduced pressure, and the residue was extracted with chloroform and purified water. The organic layer was dried over sodium sulfate anhydrate, and the solvent was evaporated to dryness. The residue was recrystallized from ethyl acetate, to thereby yield the target product (yield: 974 mg, 30%).

1. temperatureunder reflux for 2 hours
2. additionwas added to the reaction mixture
3. stirringby stirring for 30 minutes
4. customThe solvent was evaporated under reduced pressure
5. extractionthe residue was extracted with chloroform
6. custompurified water
7. dry with materialThe organic layer was dried over sodium sulfate anhydrate
8. customthe solvent was evaporated to dryness
9. customThe residue was recrystallized from ethyl acetate