3,4-Dimethoxybenzeneacetonitrile → HCID 11965737, compound

HRID 2366412Notes

Reaction equation

HRID 2366412 reaction equation
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([CH:11]=O)=[CH:3][CH:2]=1.[CH3:13][O:14][C:15]1[CH:16]=[C:17]([CH:21]=[CH:22][C:23]=1[O:24][CH3:25])[CH2:18][C:19]#[N:20]>>[CH3:13][O:14][C:15]1[CH:16]=[C:17](/[C:18](=[CH:11]/[C:4]2[C:5]3[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=3)[N:1]=[CH:2][CH:3]=2)/[C:19]#[N:20])[CH:21]=[CH:22][C:23]=1[O:24][CH3:25]

Participants

3

Reactant 2

HCID 667273,4-DimethoxybenzeneacetonitrileHCID 780724-Quinolinecarboxaldehyde

Product 1

HCID 11965737HCID 11965737, compoundYield 52%

Procedure

4-Quinolinecarboxaldehyde (500 mg) was condensed with 3,4-dimethoxybenzyl cyanide (564 mg) through Method A (production step 2), to thereby yield the target product (yield: 522 mg, 52%)

Sources & evidence

ORD record
ord-a4fc92c22d6c40309b22f8ade2bb9db3
Source dataset
uspto-grants-2014_04
Patent number
US08697742B2

Reaction notes

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