3,4-Dimethoxybenzeneacetonitrile → HCID 11965738, compound

HRID 2366413Notes

Reaction equation

HRID 2366413 reaction equation
[S:1]1[CH:5]=[C:4]([CH:6]=O)[C:3]2[CH:8]=[CH:9][CH:10]=[CH:11][C:2]1=2.[CH3:12][O:13][C:14]1[CH:15]=[C:16]([CH:20]=[CH:21][C:22]=1[O:23][CH3:24])[CH2:17][C:18]#[N:19]>>[S:1]1[CH:5]=[C:4](/[CH:6]=[C:17](/[C:16]2[CH:20]=[CH:21][C:22]([O:23][CH3:24])=[C:14]([O:13][CH3:12])[CH:15]=2)\[C:18]#[N:19])[C:3]2[CH:8]=[CH:9][CH:10]=[CH:11][C:2]1=2

Participants

3

Reactant 2

HCID 667273,4-DimethoxybenzeneacetonitrileHCID 2273281-Benzothiophene-3-carbaldehyde

Product 1

HCID 11965738HCID 11965738, compoundYield 92.3%

Procedure

Benzo[b]thiophene-3-carboxaldehyde (200 mg) was condensed with 3,4-dimethoxybenzyl cyanide (218 mg) through Method A (production step 2), to thereby yield the target product (yield: 365 mg, 92%).

Sources & evidence

ORD record
ord-9d9d9088b2fe444ebf37fb0efcf5b120
Source dataset
uspto-grants-2014_04
Patent number
US08697742B2

Reaction notes

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