3,4-Dimethoxybenzeneacetonitrile → HCID 11965739, compound

HRID 2366414Notes

Reaction equation

HRID 2366414 reaction equation
[CH3:1][N:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[N:4]=[C:3]1[CH:11]=O.[CH3:13][O:14][C:15]1[CH:16]=[C:17]([CH:21]=[CH:22][C:23]=1[O:24][CH3:25])[CH2:18][C:19]#[N:20]>>[CH3:13][O:14][C:15]1[CH:16]=[C:17](/[C:18](=[CH:11]/[C:3]2[N:2]([CH3:1])[C:6]3[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=3[N:4]=2)/[C:19]#[N:20])[CH:21]=[CH:22][C:23]=1[O:24][CH3:25]

Participants

3

Reactant 2

HCID 667273,4-DimethoxybenzeneacetonitrileHCID 7620841-methyl-1H-1,3-benzodiazole-2-carbaldehyde

Product 1

HCID 11965739HCID 11965739, compoundYield 93%

Procedure

1-Methyl-2-formylbenzimidazole (200 mg) was condensed with 3,4-dimethoxybenzyl cyanide (221 mg) through Method A (production step 2), to thereby yield the target product (yield: 369 mg, 93%).

Sources & evidence

ORD record
ord-b7de86a68c384161ad267b2e2c6d91ad
Source dataset
uspto-grants-2014_04
Patent number
US08697742B2

Reaction notes

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