3,4-Dimethoxybenzeneacetonitrile → HCID 11965740, compound

HRID 2366415Notes

Reaction equation

HRID 2366415 reaction equation
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([CH:11]=O)=[CH:3]1.[CH3:13][O:14][C:15]1[CH:16]=[C:17]([CH:21]=[CH:22][C:23]=1[O:24][CH3:25])[CH2:18][C:19]#[N:20]>>[CH3:13][O:14][C:15]1[CH:16]=[C:17](/[C:18](=[CH:11]/[C:4]2[C:5]3[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=3)[N:2]([CH3:1])[CH:3]=2)/[C:19]#[N:20])[CH:21]=[CH:22][C:23]=1[O:24][CH3:25]

Participants

3

Reactant 2

HCID 667273,4-DimethoxybenzeneacetonitrileHCID 878941-Methyl-1H-indole-3-carbaldehyde

Product 1

HCID 11965740HCID 11965740, compoundYield 73%

Procedure

1-Methylindole-3-carboxaldehyde (200 mg) was condensed with 3,4-dimethoxybenzyl cyanide (223 mg) through Method A (production step 2), to thereby yield the target product (yield: 292 mg, 73%).

Sources & evidence

ORD record
ord-3598ef95773e455aa33d66a3c8ff19f5
Source dataset
uspto-grants-2014_04
Patent number
US08697742B2

Reaction notes

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