2-Benzofurancarboxaldehyde → HCID 67228002, compound

HRID 2366416Notes

Reaction equation

HRID 2366416 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=[C:2]1[CH:10]=O.[CH3:12][O:13][C:14]1[CH:15]=[C:16]([CH:20]=[CH:21][C:22]=1[O:23][CH3:24])[CH2:17][C:18]#[N:19]>>[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=[C:2]1/[CH:10]=[C:17](/[C:16]1[CH:20]=[CH:21][C:22]([O:23][CH3:24])=[C:14]([O:13][CH3:12])[CH:15]=1)\[C:18]#[N:19]

Participants

3

Reactant 2

HCID 613412-BenzofurancarboxaldehydeHCID 667273,4-Dimethoxybenzeneacetonitrile

Product 1

HCID 67228002HCID 67228002, compoundYield 77%

Procedure

2-Benzofurancarboxaldehyde (166 mg) was condensed with 3,4-dimethoxybenzyl cyanide (201 mg) through Method A (production step 2), to thereby yield the target product (yield: 265 mg, 77%).

Sources & evidence

ORD record
ord-7be04834f8504b169f63b20203bbc6cd
Source dataset
uspto-grants-2014_04
Patent number
US08697742B2

Reaction notes

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