3,4-Dimethoxybenzeneacetonitrile → HCID 11964546, compound

HRID 2366417Notes

Reaction equation

HRID 2366417 reaction equation
[Cl:1][C:2]1[C:11]([CH:12]=O)=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[CH3:14][O:15][C:16]1[CH:17]=[C:18]([CH:22]=[CH:23][C:24]=1[O:25][CH3:26])[CH2:19][C:20]#[N:21]>>[Cl:1][C:2]1[C:11](/[CH:12]=[C:19](/[C:18]2[CH:22]=[CH:23][C:24]([O:25][CH3:26])=[C:16]([O:15][CH3:14])[CH:17]=2)\[C:20]#[N:21])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1

Participants

3

Reactant 2

HCID 667273,4-DimethoxybenzeneacetonitrileHCID 6909582-Chloro-3-quinolinecarboxaldehyde

Product 1

HCID 11964546HCID 11964546, compoundYield 85%

Procedure

2-Chloro-3-quinolinecarboxaldehyde (200 mg) was condensed with 3,4-dimethoxybenzyl cyanide (185 mg) through Method A (production step 2), to thereby yield the target product (yield: 311 mg, 85%).

Sources & evidence

ORD record
ord-dbc785005d234c0b9370e804e9464619
Source dataset
uspto-grants-2014_04
Patent number
US08697742B2

Reaction notes

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