3,4-Dimethoxybenzeneacetonitrile → HCID 11964548, compound

HRID 2366418Notes

Reaction equation

HRID 2366418 reaction equation
[Cl:1][C:2]1[C:11]([CH:12]=O)=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([O:14][CH3:15])[CH:8]=2)[N:3]=1.[CH3:16][O:17][C:18]1[CH:19]=[C:20]([CH:24]=[CH:25][C:26]=1[O:27][CH3:28])[CH2:21][C:22]#[N:23]>>[Cl:1][C:2]1[C:11](/[CH:12]=[C:21](/[C:20]2[CH:24]=[CH:25][C:26]([O:27][CH3:28])=[C:18]([O:17][CH3:16])[CH:19]=2)\[C:22]#[N:23])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([O:14][CH3:15])[CH:8]=2)[N:3]=1

Participants

3

Reactant 2

HCID 667273,4-DimethoxybenzeneacetonitrileHCID 6890792-Chloro-6-methoxyquinoline-3-carbaldehyde

Product 1

HCID 11964548HCID 11964548, compoundYield 91.3%

Procedure

2-Chloro-6-methoxy-3-quinolinecarboxaldehyde (500 mg) was condensed with 3,4-dimethoxybenzyl cyanide (400 mg) through Method A (production step 2), to thereby yield the target product (yield: 784 mg, 91%).

Sources & evidence

ORD record
ord-388f5321c4d84a1d84324007d9a05a2d
Source dataset
uspto-grants-2014_04
Patent number
US08697742B2

Reaction notes

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