3,4-Dimethoxybenzeneacetonitrile → HCID 11964549, compound

HRID 2366420Notes

Reaction equation

HRID 2366420 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH:10]=O)=[CH:9][C:4]=2[CH2:3][CH2:2]1.[CH3:12][O:13][C:14]1[CH:15]=[C:16]([CH:20]=[CH:21][C:22]=1[O:23][CH3:24])[CH2:17][C:18]#[N:19]>>[O:1]1[C:5]2[CH:6]=[CH:7][C:8](/[CH:10]=[C:17](/[C:16]3[CH:20]=[CH:21][C:22]([O:23][CH3:24])=[C:14]([O:13][CH3:12])[CH:15]=3)\[C:18]#[N:19])=[CH:9][C:4]=2[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 667273,4-DimethoxybenzeneacetonitrileHCID 7359012,3-Dihydrobenzofuran-5-carboxaldehyde

Product 1

HCID 11964549HCID 11964549, compoundYield 50%

Procedure

2,3-Dihydrobenzofuran-5-carboxaldehyde (150 mg) was condensed with 3,4-dimethoxybenzyl cyanide (180 mg) through Method A (production step 2), to thereby yield the target product (yield: 154 mg, 50%).

Sources & evidence

ORD record
ord-08c7708c049c42c9a8d919447943dbfb
Source dataset
uspto-grants-2014_04
Patent number
US08697742B2

Reaction notes

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