3,4-Dimethoxybenzeneacetonitrile → HCID 11964550, compound

HRID 2366421Notes

Reaction equation

HRID 2366421 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][N:11]=[C:10]([CH:13]=O)[CH:9]=2)=[CH:4][CH:3]=1.[CH3:15][O:16][C:17]1[CH:18]=[C:19]([CH:23]=[CH:24][C:25]=1[O:26][CH3:27])[CH2:20][C:21]#[N:22]>>[CH3:15][O:16][C:17]1[CH:18]=[C:19](/[C:20](=[CH:13]/[C:10]2[CH:9]=[C:8]([C:5]3[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=3)[O:12][N:11]=2)/[C:21]#[N:22])[CH:23]=[CH:24][C:25]=1[O:26][CH3:27]

Participants

3

Reactant 2

HCID 667273,4-DimethoxybenzeneacetonitrileHCID 162178135-(4-Fluorophenyl)isoxazole-3-carboxaldehyde

Product 1

HCID 11964550HCID 11964550, compoundYield 41%

Procedure

5-(4-Fluorophenyl)-isoxazole-3-carboxaldehyde (200 mg) was condensed with 3,4-dimethoxybenzyl cyanide (185 mg) through Method A (production step 2), to thereby yield the target product (yield: 150 mg, 41%).

Sources & evidence

ORD record
ord-9841b79221954bdbb8faaca79e9756be
Source dataset
uspto-grants-2014_04
Patent number
US08697742B2

Reaction notes

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