3,4-Dimethoxybenzeneacetonitrile → HCID 11964551, compound

HRID 2366422Notes

Reaction equation

HRID 2366422 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[O:13][N:12]=[C:11]([CH:14]=O)[CH:10]=2)=[CH:5][CH:4]=1.[CH3:16][O:17][C:18]1[CH:19]=[C:20]([CH:24]=[CH:25][C:26]=1[O:27][CH3:28])[CH2:21][C:22]#[N:23]>>[CH3:16][O:17][C:18]1[CH:19]=[C:20](/[C:21](=[CH:14]/[C:11]2[CH:10]=[C:9]([C:6]3[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:8][CH:7]=3)[O:13][N:12]=2)/[C:22]#[N:23])[CH:24]=[CH:25][C:26]=1[O:27][CH3:28]

Participants

3

Reactant 2

HCID 667273,4-DimethoxybenzeneacetonitrileHCID 162178105-(4-Methoxyphenyl)-1,2-oxazole-3-carbaldehyde

Product 1

HCID 11964551HCID 11964551, compoundYield 36%

Procedure

5-(4-Methoxyphenyl)-isoxazole-3-carboxaldehyde (200 mg) was condensed with 3,4-dimethoxybenzyl cyanide (174 mg) through Method A (production step 2), to thereby yield the target product (yield: 127 mg, 36%).

Sources & evidence

ORD record
ord-24cd80d4db784908a38e54e52dcab7dd
Source dataset
uspto-grants-2014_04
Patent number
US08697742B2

Reaction notes

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