3,4-Dimethoxybenzeneacetonitrile → HCID 11964635, compound

HRID 2366423Notes

Reaction equation

HRID 2366423 reaction equation
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH:11]=O.[CH3:13][O:14][C:15]1[CH:16]=[C:17]([CH:21]=[CH:22][C:23]=1[O:24][CH3:25])[CH2:18][C:19]#[N:20]>>[CH3:13][O:14][C:15]1[CH:16]=[C:17](/[C:18](=[CH:11]/[C:2]2[CH:3]=[CH:4][C:5]3[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=3)[N:1]=2)/[C:19]#[N:20])[CH:21]=[CH:22][C:23]=1[O:24][CH3:25]

Participants

3

Reactant 2

HCID 667273,4-DimethoxybenzeneacetonitrileHCID 796192-Quinolinecarboxaldehyde

Product 1

HCID 11964635HCID 11964635, compoundYield 63%

Procedure

2-Quinolinecarboxaldehyde (200 mg) was condensed with 3,4-dimethoxybenzyl cyanide (225 mg) through Method A (production step 2), to thereby yield the target product (yield: 252 mg, 63%).

Sources & evidence

ORD record
ord-59b2ad71e0b64819a548c4179ac22efd
Source dataset
uspto-grants-2014_04
Patent number
US08697742B2

Reaction notes

Loading…