3-Pyridineacetonitrile → HCID 11964636, compound

HRID 2366425Notes

Reaction equation

HRID 2366425 reaction equation
[Cl:1][C:2]1[C:11]([CH:12]=O)=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([O:14][CH3:15])[CH:8]=2)[N:3]=1.[N:16]1[CH:21]=[CH:20][CH:19]=[C:18]([CH2:22][C:23]#[N:24])[CH:17]=1>>[Cl:1][C:2]1[C:11](/[CH:12]=[C:22](/[C:18]2[CH:17]=[N:16][CH:21]=[CH:20][CH:19]=2)\[C:23]#[N:24])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([O:14][CH3:15])[CH:8]=2)[N:3]=1

Participants

3

Reactant 2

HCID 809233-PyridineacetonitrileHCID 6890792-Chloro-6-methoxyquinoline-3-carbaldehyde

Product 1

HCID 11964636HCID 11964636, compoundYield 78.1%

Procedure

2-Chloro-6-methoxy-3-quinolinecarboxaldehyde (222 mg) was condensed with 3-pyridineacetonitrile (118 mg) through Method B (production step 3), to thereby yield the target product (yield: 251 mg, 78%).

Sources & evidence

ORD record
ord-5cf618b461ad4e95b5f04ed43772e8e1
Source dataset
uspto-grants-2014_04
Patent number
US08697742B2

Reaction notes

Loading…