3-Thienylacetonitrile → HCID 11964638, compound

HRID 2366427Notes

Reaction equation

HRID 2366427 reaction equation
[Cl:1][C:2]1[C:11]([CH:12]=O)=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([O:14][CH3:15])[CH:8]=2)[N:3]=1.[S:16]1[CH:20]=[CH:19][C:18]([CH2:21][C:22]#[N:23])=[CH:17]1>>[Cl:1][C:2]1[C:11](/[CH:12]=[C:21](/[C:18]2[CH:19]=[CH:20][S:16][CH:17]=2)\[C:22]#[N:23])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([O:14][CH3:15])[CH:8]=2)[N:3]=1

Participants

3

Reactant 2

HCID 837303-ThienylacetonitrileHCID 6890792-Chloro-6-methoxyquinoline-3-carbaldehyde

Product 1

HCID 11964638HCID 11964638, compoundYield 83.7%

Procedure

2-Chloro-6-methoxy-3-quinolinecarboxaldehyde (222 mg) was condensed with 3-thiopheneacetonitrile (123 mg) through Method B (production step 3), to thereby yield the target product (yield: 273 mg, 83%).

Sources & evidence

ORD record
ord-a61691d54c5442c087e386ad1dd0e42d
Source dataset
uspto-grants-2014_04
Patent number
US08697742B2

Reaction notes

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