2-Chloro-6-methoxyquinoline-3-carbaldehyde → HCID 11964639, compound

HRID 2366428Notes

Reaction equation

HRID 2366428 reaction equation
[Cl:1][C:2]1[C:11]([CH:12]=O)=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([O:14][CH3:15])[CH:8]=2)[N:3]=1.[N:16]1([CH2:25][C:26]#[N:27])[C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=2[N:18]=[N:17]1>>[N:16]1(/[C:25](=[CH:12]/[C:11]2[C:2]([Cl:1])=[N:3][C:4]3[C:9]([CH:10]=2)=[CH:8][C:7]([O:14][CH3:15])=[CH:6][CH:5]=3)/[C:26]#[N:27])[C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=2[N:18]=[N:17]1

Participants

3

Reactant 2

HCID 6890792-Chloro-6-methoxyquinoline-3-carbaldehydeHCID 7863021H-Benzotriazole-1-acetonitrile

Product 1

HCID 11964639HCID 11964639, compoundYield 71.4%

Procedure

2-Chloro-6-methoxy-3-quinolinecarboxaldehyde (111 mg) was condensed with 1H-benzotriazole-1-acetonitrile (79 mg) through Method B (production step 3), to thereby yield the target product (yield: 129 mg, 71%).

Sources & evidence

ORD record
ord-03377743db2c42f5a143468b4f7bc727
Source dataset
uspto-grants-2014_04
Patent number
US08697742B2

Reaction notes

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