2-(1,3-Benzothiazol-2-yl)acetonitrile → HCID 8273172, compound

HRID 2366429Notes

Reaction equation

HRID 2366429 reaction equation
[Cl:1][C:2]1[C:11]([CH:12]=O)=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([O:14][CH3:15])[CH:8]=2)[N:3]=1.[S:16]1[C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=2[N:18]=[C:17]1[CH2:25][C:26]#[N:27]>>[S:16]1[C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=2[N:18]=[C:17]1/[C:25](=[CH:12]/[C:11]1[C:2]([Cl:1])=[N:3][C:4]2[C:9]([CH:10]=1)=[CH:8][C:7]([O:14][CH3:15])=[CH:6][CH:5]=2)/[C:26]#[N:27]

Participants

3

Reactant 2

HCID 3424652-(1,3-Benzothiazol-2-yl)acetonitrileHCID 6890792-Chloro-6-methoxyquinoline-3-carbaldehyde

Product 1

HCID 8273172HCID 8273172, compoundYield 78.4%

Procedure

2-Chloro-6-methoxy-3-quinolinecarboxaldehyde (111 mg) was condensed with 2-benzothiazoleacetonitrile (87 mg) through Method B (production step 3), to thereby yield the target product (yield: 148 mg, 78%).

Sources & evidence

ORD record
ord-0b708e5a096a4b2aaf4ab25b24df9e51
Source dataset
uspto-grants-2014_04
Patent number
US08697742B2

Reaction notes

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