4-Quinolinecarboxaldehyde → HCID 11964706, compound

HRID 2366431Notes

Reaction equation

HRID 2366431 reaction equation
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([CH:11]=O)=[CH:3][CH:2]=1.[N:13]1[CH:18]=[CH:17][CH:16]=[C:15]([CH2:19][C:20]#[N:21])[CH:14]=1>>[N:13]1[CH:18]=[CH:17][CH:16]=[C:15](/[C:19](=[CH:11]/[C:4]2[C:5]3[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=3)[N:1]=[CH:2][CH:3]=2)/[C:20]#[N:21])[CH:14]=1

Participants

3

Reactant 2

HCID 780724-QuinolinecarboxaldehydeHCID 809233-Pyridineacetonitrile

Product 1

HCID 11964706HCID 11964706, compoundYield 29.6%

Procedure

4-Quinolinecarboxaldehyde (157 mg) was condensed with 3-pyridineacetonitrile (118 mg) through Method B (production step 3), to thereby yield the target product (yield: 76 mg, 29%).

Sources & evidence

ORD record
ord-1d565635fa1c49bbb9742c57e7ac12b7
Source dataset
uspto-grants-2014_04
Patent number
US08697742B2

Reaction notes

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