2-Thienylacetonitrile → HCID 11964707, compound

HRID 2366432Notes

Reaction equation

HRID 2366432 reaction equation
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([CH:11]=O)=[CH:3][CH:2]=1.[S:13]1[CH:17]=[CH:16][CH:15]=[C:14]1[CH2:18][C:19]#[N:20]>>[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4](/[CH:11]=[C:18](/[C:14]2[S:13][CH:17]=[CH:16][CH:15]=2)\[C:19]#[N:20])=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 728802-ThienylacetonitrileHCID 780724-Quinolinecarboxaldehyde

Product 1

HCID 11964707HCID 11964707, compoundYield 67%

Procedure

4-Quinolinecarboxaldehyde (157 mg) was condensed with 2-thiopheneacetonitrile (123 mg) through Method B (production step 3), to thereby yield the target product (yield: 175 mg, 67%).

Sources & evidence

ORD record
ord-0dce3098245b453fa8ef3abc4242c74a
Source dataset
uspto-grants-2014_04
Patent number
US08697742B2

Reaction notes

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