4-Quinolinecarboxaldehyde → HCID 11964708, compound

HRID 2366433Notes

Reaction equation

HRID 2366433 reaction equation
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([CH:11]=O)=[CH:3][CH:2]=1.[S:13]1[CH:17]=[CH:16][C:15]([CH2:18][C:19]#[N:20])=[CH:14]1>>[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4](/[CH:11]=[C:18](/[C:15]2[CH:16]=[CH:17][S:13][CH:14]=2)\[C:19]#[N:20])=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 780724-QuinolinecarboxaldehydeHCID 837303-Thienylacetonitrile

Product 1

HCID 11964708HCID 11964708, compoundYield 31%

Procedure

4-Quinolinecarboxaldehyde (157 mg) was condensed with 3-thiopheneacetonitrile (123 mg) through Method B (production step 3), to thereby yield the target product (yield: 81 mg, 31%).

Sources & evidence

ORD record
ord-cf853dd063784a2ba87e9302e75b4d36
Source dataset
uspto-grants-2014_04
Patent number
US08697742B2

Reaction notes

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