2-Thienylacetonitrile → HCID 11964709, compound

HRID 2366434Notes

Reaction equation

HRID 2366434 reaction equation
[S:1]1[CH:5]=[C:4]([CH:6]=O)[C:3]2[CH:8]=[CH:9][CH:10]=[CH:11][C:2]1=2.[S:12]1[CH:16]=[CH:15][CH:14]=[C:13]1[CH2:17][C:18]#[N:19]>>[S:1]1[CH:5]=[C:4](/[CH:6]=[C:17](/[C:13]2[S:12][CH:16]=[CH:15][CH:14]=2)\[C:18]#[N:19])[C:3]2[CH:8]=[CH:9][CH:10]=[CH:11][C:2]1=2

Participants

3

Reactant 2

HCID 728802-ThienylacetonitrileHCID 2273281-Benzothiophene-3-carbaldehyde

Product 1

HCID 11964709HCID 11964709, compoundYield 30%

Procedure

Benzo[b]thiophene-3-carboxaldehyde (81 mg) was condensed with 2-thiopheneacetonitrile (62 mg) through Method B (production step 3), to thereby yield the target product (yield: 40 mg, 30%).

Sources & evidence

ORD record
ord-9d93f42905e4420ca9e65e5439f13d54
Source dataset
uspto-grants-2014_04
Patent number
US08697742B2

Reaction notes

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