1-Methyl-1H-indole-3-carbaldehyde → HCID 11964712, compound

HRID 2366436Notes

Reaction equation

HRID 2366436 reaction equation
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([CH:11]=O)=[CH:3]1.[S:13]1[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=2[N:15]=[C:14]1[CH2:22][C:23]#[N:24]>>[S:13]1[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=2[N:15]=[C:14]1/[C:22](=[CH:11]/[C:4]1[C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[N:2]([CH3:1])[CH:3]=1)/[C:23]#[N:24]

Participants

3

Reactant 2

HCID 878941-Methyl-1H-indole-3-carbaldehydeHCID 3424652-(1,3-Benzothiazol-2-yl)acetonitrile

Product 1

HCID 11964712HCID 11964712, compoundYield 100.3%

Procedure

1-Methylindole-3-carboxaldehyde (79 mg) was condensed with 2-benzothiazoleacetonitrile (87 mg) through Method B (production step 3), to thereby yield the target product (yield: 157 mg, 99%).

Sources & evidence

ORD record
ord-d998724f66f048f1844dee4245d3b2e3
Source dataset
uspto-grants-2014_04
Patent number
US08697742B2

Reaction notes

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