HCID 69260969, compound → HCID 16665624, compound

Participants

Reaction Steps

A suspension of EXAMPLE 20A in acetic acid at reflux was stirred for 2 hours, cooled and concentrated. The concentrate was dissolved in ethyl acetate, washed with sodium bicarbonate and water and concentrated. The concentrate was flash chromatographed on silica gel with 20% Methanol/ethyl acetate. 1H NMR (DMSO-d6) δ 1.27-1.44 (m, 2H), 1.75 (d, J=13.20 Hz, 2H), 1.82-1.97 (m, 1H), 2.65 (d, J=7.06 Hz, 2H), 2.76-2.92 (m, 2H), 3.26 (d, J=12.89 Hz, 2H), 7.35 (t, J=7.83 Hz, 1H), 7.42 (d, J=8.29 Hz, 2H), 7.74 (d, J=0.92 Hz, 1H), 7.76 (d, J=0.92 Hz, 1H), 7.87 (d, J=6.75 Hz, 1H), 8.18 (d, J=8.29 Hz, 2H), 8.25 (d, J=7.98 Hz, 1H), 8.55 (d, J=11.97 Hz, 1H), 9.26 (s, 1H).

Provenance & Evidence